Partly. Excel has no Linux version and Microsoft's system requirements cover only Windows and macOS, but Excel for the web works in a browser on Linux and free suites open .xlsx files.
Microsoft Excel by Microsoft · Office & documents · Works in a browser
Microsoft does not make Excel for Linux. The Microsoft 365 home system requirements list Windows and recent
macOS versions only. Excel is also the Office app people lean on hardest, so it is worth being careful here
rather than optimistic.
Excel for the web covers ordinary household and small business spreadsheets. Formulas, sorting, charts and
filters all work in the browser. What it does not do is the heavy end: Power Query, Power Pivot, most add-ins
and Visual Basic macros. If your workbook has buttons that run macros, the browser will not run them, and
neither will any Linux alternative.
Offline, LibreOffice Calc and ONLYOFFICE both open .xlsx. Everyday formulas convert fine. Conditional
formatting, pivot tables and charts usually survive but can look different, and very large workbooks are
slower than in Excel.
The practical test takes ten minutes. Open your three most important workbooks in one of these before you
wipe Windows, check the numbers at the bottom of each sheet still match, and keep a copy of the originals.